{"id":121,"date":"2021-12-16T15:30:09","date_gmt":"2021-12-16T06:30:09","guid":{"rendered":"http:\/\/made-in-shibuya.tokyo\/libraclinic\/?post_type=levitrageneric&#038;p=121"},"modified":"2026-02-06T11:36:55","modified_gmt":"2026-02-06T02:36:55","slug":"contraindication","status":"publish","type":"levitra_generic","link":"http:\/\/made-in-shibuya.tokyo\/libraclinic\/levitra_generic\/contraindication\/","title":{"rendered":"\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u4f75\u7528\u7981\u5fcc\u85ac\u3001\u51e6\u65b9\u7981\u5fcc\u306b\u3064\u3044\u3066\u89e3\u8aac\u3010\u533b\u5e2b\u76e3\u4fee\u3011"},"content":{"rendered":"\n<div class=\"article-cta-head\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3092\u304a\u6c42\u3081\u306e\u65b9\u306f\u3001\u304a\u6c17\u8efd\u306b<a href=\"https:\/\/men.libraclinic.com\/online\/\">\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642<\/a>\u3092\u304a\u7533\u3057\u8fbc\u307f\u304f\u3060\u3055\u3044\u3002\u500b\u4eba\u8f38\u5165\u306a\u3069\u3067\u8d77\u3053\u308b\u507d\u7269\u306e\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6765\u9662\u4e0d\u8981\u3067\u304b\u304b\u308b\u8cbb\u7528\u306f\u304a\u85ac\u4ee3\u3068\u9001\u6599\u306e\u307f\u3067\u3059\u3002<a href=\"https:\/\/men.libraclinic.com\/online\/\" class=\"c-button1\">\u30aa\u30f3\u30e9\u30a4\u30f3\u8a3a\u7642\u3092\u4e88\u7d04\u3059\u308b<\/a><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u30b7\u30a2\u30ea\u30b9\u306e\u51e6\u65b9\u7981\u5fcc\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u670d\u7528\u306b\u304a\u3044\u3066\u6ce8\u610f\u3059\u3079\u304d\u3053\u3068<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3092\u670d\u7528\u3059\u308b\u969b\u3001\u7279\u306b\u6ce8\u610f\u3059\u3079\u304d\u70b9\u3068\u3057\u3066\u306f\u3001\u5148\u767a\u533b\u85ac\u54c1\u3067\u3042\u308b\u30ec\u30d3\u30c8\u30e9\u3068\u540c\u69d8\u306b<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u904e\u5ea6\u306a\u8840\u5727\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u85ac\u5264\u304c\u5b58\u5728\u3059\u308b<\/li>\n\n\n\n<li>\u6cbb\u7642\u4e2d\u306e\u3082\u306e\u3082\u542b\u3081\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u969c\u5bb3\u304c\u3042\u308b\u5834\u5408\u3001\u6b7b\u4ea1\u306b\u81f3\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u524d\u80051\u306f\u300c\u4f75\u7528\u7981\u5fcc\u85ac\u300d\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3067\u3001\u53b3\u91cd\u306a\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f8c\u80052\u306f\u3044\u308f\u3086\u308b\u300c\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3092\u98f2\u3093\u3067\u306f\u3044\u3051\u306a\u3044\u4eba\u300d\u306b\u3042\u305f\u308a\u3001\u670d\u7528\u524d\u306b\u5fc3\u8840\u7ba1\u7cfb\u969c\u5bb3\u306e\u6709\u7121\u306b\u3064\u3044\u3066\u5fc5\u305a\u4e3b\u6cbb\u533b\u306b\u78ba\u8a8d\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u4f75\u7528\u7981\u5fcc\u85ac<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306e\u65b9\u306f\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3092\u670d\u7528\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u72ed\u5fc3\u75c7\u306a\u3069\u3067\u3001\u785d\u9178\u85ac\uff08\u98f2\u307f\u85ac\u30fb\u820c\u4e0b\u9320\u30fb\u8cbc\u308a\u85ac\u30fb\u6ce8\u5c04\u30fb\u5438\u5165\u5264\u306a\u3069\uff09\u3067\u6cbb\u7642\u4e2d\u306e\u65b9<\/li>\n\n\n\n<li>\u6162\u6027\u5fc3\u4e0d\u5168\u306a\u3069\u3067\u3001sGC\u523a\u6fc0\u5264\uff08\u30a2\u30c7\u30e0\u30d1\u30b9\u306a\u3069\uff09\u3067\u6cbb\u7642\u4e2d\u306e\u65b9<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>\u85ac\u5264\u540d\u7b49<\/th><th>\u81e8\u5e8a\u75c7\u72b6\u30fb\u63aa\u7f6e\u65b9\u6cd5<\/th><th>\u6a5f\u5e8f\u30fb\u5371\u967a\u56e0\u5b50<\/th><\/tr><\/thead><tbody><tr><td>\u785d\u9178\u5264\u53ca\u3073NO\u4f9b\u4e0e\u5264<br>\u30fb\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3<br>\u30fb\u4e9c\u785d\u9178\u30a2\u30df\u30eb<br>\u30fb\u785d\u9178\u30a4\u30bd\u30bd\u30eb\u30d3\u30c9<br>\u30fb\u30cb\u30b3\u30e9\u30f3\u30b8\u30eb\u7b49<\/td><td>\u4f75\u7528\u306b\u3088\u308a\u964d\u5727\u4f5c\u7528\u304c\u5897\u5f37\u3057\u3001\u904e\u5ea6\u306b\u8840\u5727\u3092\u4e0b\u964d\u3055\u305b\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/td><td>NO\u306fcGMP\u306e\u7523\u751f\u3092\u523a\u6fc0\u3057\u3001\u4e00\u65b9\u3001\u672c\u5264\u306fcGMP\u306e\u5206\u89e3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u4e21\u5264\u306e\u4f75\u7528\u306b\u3088\u308acGMP\u306e\u5897\u5927\u3092\u4ecb\u3059\u308bNO\u306e\u964d\u5727\u4f5c\u7528\u304c\u5897\u5f37\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30ea\u30aa\u30b7\u30b0\u30a2\u30c8\uff08\u30a2\u30c7\u30e0\u30d1\u30b9\uff09<\/td><td>\u75c7\u5019\u6027\u4f4e\u8840\u5727\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308b\u3002<\/td><td>\u7d30\u80de\u5185 cGMP\u6fc3\u5ea6\u304c\u5897\u52a0\u3057\u3001\u5168\u8eab\u8840\u5727\u306b\u76f8\u52a0\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><\/tr><tr><td>CYP3A4\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264<br>\u30fb\u30ea\u30c8\u30ca\u30d3\u30eb\uff08\u30ce\u30fc\u30d3\u30a2\uff09<\/td><td>\u672c\u5264\u306eAUC0-24\u304c 49\u500d\u306b\u5897\u52a0\u3057\u3001Cmax\u304c13\u500d\u306b\u4e0a\u6607\u3057\u3001\u534a\u6e1b\u671f\u304c10\u500d\u306b\u5ef6\u9577\u3059\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30fb\u30a2\u30bf\u30b6\u30ca\u30d3\u30eb\uff08\u30ec\u30a4\u30a2\u30bf\u30c3\u30c4\uff09<br>\u30fb\u30db\u30b9\u30a2\u30f3\u30d7\u30ec\u30ca\u30d3\u30eb\uff08\u30ec\u30af\u30b7\u30f4\u30a1\uff09<br>\u30fb\u30ed\u30d4\u30ca\u30d3\u30eb\u30fb\u30ea\u30c8\u30ca\u30d3\u30eb\uff08\u30ab\u30ec\u30c8\u30e9\uff09<br>\u30fb\u30c0\u30eb\u30ca\u30d3\u30eb\u3092\u542b\u6709\u3059\u308b\u88fd\u5264\uff08\u30d7\u30ea\u30b8\u30b9\u30bf\u3001\u30d7\u30ec\u30b8\u30b3\u30d3\u30c3\u30af\u30b9\u3001 \u30b7\u30e0\u30c4\u30fc\u30b6\uff09<\/td><td>\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u534a\u6e1b\u671f\u304c\u5ef6\u9577\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30fb\u30b1\u30c8\u30b3\u30ca\u30be\u30fc\u30eb\uff08\u5916\u7528\u5264\u3092\u9664\u304f\uff09\uff08\u7d4c\u53e3\u5264\u306f\u56fd\u5185\u672a\u767a\u58f2\uff09<br>\u30fb\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\uff08\u30a4\u30c8\u30ea\u30be\u30fc\u30eb\uff09<\/td><td>\u672c\u5264\u306e AUC\u304c 10\u500d\u306b\u5897\u52a0\u3057\u3001Cmax\u304c4\u500d\u306b\u4e0a\u6607\u3059\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30fb\u30a8\u30f3\u30b7\u30c8\u30ec\u30eb\u30d3\u30eb\uff08\u30be\u30b3\u30fc\u30d0\uff09<\/td><td>\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30fb\u30b3\u30d3\u30b7\u30b9\u30bf\u30c3\u30c8\u3092\u542b\u6709\u3059\u308b\u88fd\u5264\uff08\u30b9\u30bf\u30ea\u30d3\u30eb\u30c9\u3001\u30b2\u30f3\u30dc\u30a4\u30e4\u3001 \u30d7\u30ec\u30b8\u30b3\u30d3\u30c3\u30af\u30b9\u3001\u30b7\u30e0\u30c4\u30fc\u30b6\uff09<\/td><td>\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>\u30b3\u30d3\u30b7\u30b9\u30bf\u30c3\u30c8\u306eCYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30af\u30e9\u30b9\u2160A\u6297\u4e0d\u6574\u8108\u85ac<br>\u30fb\u30ad\u30cb\u30b8\u30f3<br>\u30fb\u30d7\u30ed\u30ab\u30a4\u30f3\u30a2\u30df\u30c9\uff08\u30a2\u30df\u30b5\u30ea\u30f3\uff09<br>\u30fb\u30b8\u30bd\u30d4\u30e9\u30df\u30c9\uff08\u30ea\u30b9\u30e2\u30c0\u30f3\uff08\u7d4c\u53e3\u5264\uff09\uff09<br>\u30fb\u30b7\u30d9\u30f3\u30be\u30ea\u30f3\uff08\u30b7\u30d9\u30ce\u30fc\u30eb\uff09<br>\u30fb\u30d4\u30eb\u30e1\u30ce\u30fc\u30eb\uff08\u30d4\u30e1\u30ce\u30fc\u30eb\uff09<br><br>\u30af\u30e9\u30b9\u2162\u6297\u4e0d\u6574\u8108\u85ac<br>\u30fb\u30a2\u30df\u30aa\u30c0\u30ed\u30f3\uff08\u30a2\u30f3\u30ab\u30ed\u30f3\uff08\u7d4c\u53e3\u5264\uff09\uff09<br>\u30fb\u30bd\u30bf\u30ed\u30fc\u30eb\uff08\u30bd\u30bf\u30b3\u30fc\u30eb\uff09<\/td><td>\u672c\u5264\u306e\u5fc3\u81d3\u4f1d\u5c0e\u7cfb\u3078\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u81e8\u5e8a\u85ac\u7406\u8a66\u9a13\u306b\u304a\u3044\u3066\u672c\u5264\u6295\u4e0e\u306b\u3088\u308bQTc\u5ef6\u9577\u304c\u307f\u3089\u308c\u3066\u3044\u308b\u3002<\/td><td>\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u3044\u305a\u308c\u3082QTc\u5ef6\u9577\u4f5c\u7528\u304c\u307f\u3089\u308c\u3066\u3044\u308b\u3002\u672c\u5264\u3092\u4f75\u7528\u3057\u305f\u5834\u5408\u3001\u76f8\u52a0\u7684\u306aQTc\u5ef6\u9577\u304c\u307f\u3089\u308c\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3068\u306e\u4f75\u7528\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u3082\u306e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3068\u306e\u4f75\u7528\u306b\u304a\u3044\u3066\u3001\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u3082\u306e\u306f\u4ee5\u4e0b\u306e\u8868\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306e\u85ac\u3068\u4f75\u7528\u3059\u308b\u3068\u4f53\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5371\u967a\u6027\u304c\u3042\u308b\u306e\u3067\u3001\u53d7\u8a3a\u306e\u969b\u306b\u306f\u73fe\u5728\u670d\u7528\u3057\u3066\u3044\u308b\u85ac\u306e\u540d\u524d\u304c\u5206\u304b\u308b\u3088\u3046\u306b\u3057\u3066\u304a\u3044\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u4ed6\u306b\u3082\u98f2\u3093\u3067\u3044\u308b\u85ac\u304c\u3042\u308c\u3070\u3001\u5fc5\u305a\u305d\u306e\u3053\u3068\u3092\u533b\u5e2b\u307e\u305f\u306f\u85ac\u5264\u5e2b\u306b\u304a\u8a71\u3057\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u03b1\u906e\u65ad\u85ac\uff08\u6392\u5c3f\u969c\u5bb3\u3084\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u85ac\uff09\u3068\u306e\u4f75\u7528\u306b\u6ce8\u610f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3068\u03b1\u906e\u65ad\u85ac\uff08\u6392\u5c3f\u969c\u5bb3\u3084\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u85ac\uff09\u3068\u3092\u4e00\u7dd2\u306b\u670d\u7528\u3059\u308b\u3053\u3068\u3067\u3001<span class=\"marker-yellow\">\u300c\u3081\u307e\u3044\u300d\u300c\u7acb\u3061\u304f\u3089\u307f\u300d\u306a\u3069\u304c\u8d77\u3053\u308b\u304a\u305d\u308c<\/span>\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u6240\u3067\u306e\u4f5c\u696d\u3001\u81ea\u52d5\u8eca\u306e\u904b\u8ee2\u306a\u3069\u5371\u967a\u3092\u4f34\u3046\u6a5f\u68b0\u3092\u64cd\u4f5c\u3059\u308b\u6642\u306f\u5341\u5206\u3054\u6ce8\u610f\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6297\u771f\u83cc\u85ac\uff08\u6c34\u866b\u6cbb\u7642\u85ac\uff09\u3068\u306e\u4f75\u7528\u306b\u6ce8\u610f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u306a\u3044<span class=\"marker-yellow\">\u4f75\u7528\u7981\u5fcc\u85ac\u3067\u3001\u5185\u670d\u3059\u308b\u30bf\u30a4\u30d7\u306e\u6297\u771f\u83cc\u85ac\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u771f\u83cc\u85ac\u3068\u306f\u6c34\u866b\u306a\u3069\u306e\u30ab\u30d3\u306b\u3088\u308b\u611f\u67d3\u75c7\u306e\u6cbb\u7642\u85ac\u306e\u3053\u3068\u3067\u3001<span class=\"marker-yellow\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u982d\u75db\u3084\u52d5\u60b8\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u3044\u3063\u305d\u3046\u5f37\u304f\u73fe\u308c\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u6297\u771f\u83cc\u85ac\u3067\u3082\u5185\u670d\u30bf\u30a4\u30d7\u306e\u85ac\u306f\u4f75\u7528\u7981\u5fcc\u3067\u3059\u304c\u3001\u5916\u7528\u30bf\u30a4\u30d7\u306e\u3082\u306e\u3067\u3042\u308c\u3070\u4f75\u7528\u3057\u3066\u3082\u554f\u984c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3088\u3046\u306bED\u306b\u306f\u5168\u304f\u95a2\u4fc2\u306e\u306a\u3044\u6c34\u866b\u6cbb\u7642\u85ac\u3082ED\u6cbb\u7642\u85ac\u3068\u4f75\u7528\u3059\u308b\u3068\u554f\u984c\u304c\u3042\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002ED\u6cbb\u7642\u85ac\u306e\u4f75\u7528\u7981\u5fcc\u85ac\u306f\u785d\u9178\u5264\u3084\u6c34\u866b\u6cbb\u7642\u85ac\u3060\u3051\u306b\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3082\u3057<span class=\"marker-yellow\">\u5e38\u7528\u3057\u3066\u3044\u308b\u85ac\u304c\u3042\u3063\u305f\u308a\u3001\u4ed6\u306e\u75c5\u6c17\u306e\u6cbb\u7642\u3067\u670d\u7528\u3057\u3066\u3044\u308b\u85ac\u304c\u3042\u308b\u5834\u5408\u306f\u5fc5\u305a\u3001\u4f55\u306e\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u670d\u7528\u3057\u3066\u3044\u308b\u85ac\u306e\u540d\u524d\u3092\u5206\u304b\u308b\u3088\u3046\u306b\u3057\u305f\u4e0a\u3067\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/span>\u300c\u591a\u5206\u5927\u4e08\u592b\u3060\u308d\u3046\u300d\u3068\u81ea\u8eab\u3067\u5224\u65ad\u3059\u308b\u306e\u306f\u975e\u5e38\u306b\u5371\u967a\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>\u85ac\u5264\u540d\u7b49<\/th><th>\u81e8\u5e8a\u75c7\u72b6\u30fb\u63aa\u7f6e\u65b9\u6cd5<\/th><th>\u6a5f\u5e8f\u30fb\u5371\u967a\u56e0\u5b50<\/th><\/tr><\/thead><tbody><tr><td>CYP3A4\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264<br>\u30fb\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u7cfb<br>\u6297\u751f\u7269\u8cea\uff08\u30a8\u30ea\u30b9 \u30ed\u30de\u30a4\u30b7\u30f3\u7b49\uff09<\/td><td>\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3067\u3001\u672c\u5264\u306eAUC\u304c4\u500d\u306b\u5897\u52a0\u3057\u3001Cmax\u304c3\u500d\u306b\u4e0a\u6607\u3059\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30ab\u30eb\u30bf\u30df\u30c9<\/td><td>\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>CYP3A4\u3092\u8a98\u5c0e\u3059\u308b\u85ac\u5264<br>\u30fb\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3\u7b49<\/td><td>\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>CYP3A4\u963b\u5bb3\u306b\u3088\u308a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30ab\u30eb\u30da\u30ea\u30c1\u30c9<\/td><td>\u4f75\u7528\u306b\u3088\u308a\u3001\u964d\u5727\u4f5c\u7528\u304c\u5897\u5f37\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><td>\u672c\u5264\u306f\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\u306b\u3088\u308b\u964d\u5727\u4f5c\u7528\u3092\u6709\u3059\u308b\u305f\u3081\u3001\u4f75\u7528\u306b\u3088\u308a\u964d\u5727\u4f5c\u7528\u304c\u5897\u5f37\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002<\/td><\/tr><tr><td>\u03b1\u906e\u65ad\u85ac<br>\u30fb\u30c6\u30e9\u30be\u30b7\u30f3<br>\u30fb\u30bf\u30e0\u30b9\u30ed\u30b7\u30f3\u7b49<\/td><td>\u4f75\u7528\u306b\u3088\u308a\u3001\u75c7\u5019\u6027\u4f4e\u8840\u5727\u304c\u3042\u3089\u308f\u308c\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u306e\u3067\u3001\u03b1\u906e\u65ad\u85ac\u3068\u4f75\u7528\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u03b1\u906e\u65ad\u85ac\u3068\u306e\u6295\u4e0e\u9593\u9694\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u3002<\/td><td>\u672c\u5264\u306f\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\u306b\u3088\u308b\u964d\u5727\u4f5c\u7528\u3092\u6709\u3059\u308b\u305f\u3081\u3001\u4f75\u7528\u306b\u3088\u308b\u964d\u5727\u4f5c\u7528\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u3092\u98f2\u3093\u3067\u306f\u3044\u3051\u306a\u3044\u4eba\uff08\u51e6\u65b9\u7981\u5fcc\uff09<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b21\u306b\u8a72\u5f53\u3059\u308b\u65b9\u306f\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\uff08\u30ec\u30d3\u30c8\u30e9\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09\u306e\u51e6\u65b9\u304c\u3067\u304d\u307e\u305b\u3093\u306e\u3067\u3054\u6ce8\u610f\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u785d\u9178\u5264\u3092\u4f7f\u7528\u4e2d\u306e\u65b9<\/li>\n\n\n\n<li>\u30ec\u30d3\u30c8\u30e9\u30fb\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb\u3092\u670d\u7528\u3057\u3066\u3001\u904e\u654f\u75c7\uff08\u30a2\u30ec\u30eb\u30ae\u30fc\uff09\u3092\u8d77\u3053\u3057\u305f\u3053\u3068\u306e\u3042\u308b\u65b9<\/li>\n\n\n\n<li>\u5fc3\u8840\u7ba1\u7cfb\u969c\u5bb3\u306a\u3069\u306b\u3088\u308a\u3001\u533b\u5e2b\u304b\u3089\u6027\u884c\u70ba\u304c\u4e0d\u9069\u5f53\u3060\u3068\u8a3a\u65ad\u3055\u308c\u305f\u65b9<\/li>\n\n\n\n<li>\u5148\u5929\u7684\u306b\u4e0d\u6574\u8108\uff08QT\u5ef6\u9577\u75c7\u5019\u7fa4\uff09\u304c\u3042\u308b\u65b9\u3084\u3001\u73fe\u5728\u3001\u6297\u4e0d\u6574\u8108\u85ac\u3092\u4f7f\u7528\u4e2d\u306e\u65b9<\/li>\n\n\n\n<li>\u6700\u8fd16\u30f5\u6708\u4ee5\u5185\u306b\u8133\u6897\u585e\u30fb\u8133\u51fa\u8840\u3084\u5fc3\u7b4b\u6897\u585e\u3092\u8d77\u3053\u3057\u305f\u65b9<\/li>\n\n\n\n<li>\u91cd\u3044\u809d\u969c\u5bb3\u306e\u3042\u308b\u65b9<\/li>\n\n\n\n<li>\u8840\u6db2\u900f\u6790\u304c\u5fc5\u8981\u306a\u814e\u969c\u5bb3\u306e\u3042\u308b\u65b9<\/li>\n\n\n\n<li>\u4f4e\u8840\u5727\uff08\u6700\u5927\u8840\u5727\uff1c90mmHg\uff09\u306e\u65b9<\/li>\n\n\n\n<li>\u9ad8\u8840\u5727\uff08\u6700\u5927\u8840\u5727\uff1e170mmHg\u307e\u305f\u306f\u6700\u5c0f\u8840\u5727\uff1e100mmHg\uff09\u306e\u65b9<\/li>\n\n\n\n<li>\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u65b9<\/li>\n\n\n\n<li>\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\uff08HIV\u6cbb\u7642\u85ac\uff09\u3001\u6297\u771f\u83cc\u85ac\uff08\u5185\u670d\uff09\u3092\u4f7f\u7528\u4e2d\u306e\u65b9<\/li>\n\n\n\n<li>\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\uff08\u9032\u884c\u6027\u306e\u591c\u76f2\uff09\u306e\u65b9<\/li>\n\n\n\n<li>\u5973\u6027\u306e\u65b9<\/li>\n\n\n\n<li>20\u6b73\u672a\u6e80\u306e\u65b9<\/li>\n<\/ol>\n\n\n\n<h2 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